Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.

Tavernier, Jan; Tuypens, T; Verhee, Annick; Plaetinck, Geert; Devos, René; Van der Heyden, José; Guisez, Yves; Oefner, Christian

doi:10.1073/pnas.92.11.5194

Public

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.

Published in Proceedings of the National Academy of Sciences • May 23, 1995

Authors:

Jan Tavernier

T Tuypens

Annick Verhee

Abstract

A detailed structure-function analysis of human interleukin 5 (hIL5) has been performed. The hIL5 receptor is composed of two different polypeptide chains, the alpha and beta subunits. The alpha subunit alone is sufficient for ligand binding, but association with the beta subunit leads to a 2- to 3-...

Subject

Interleukin 10 receptor

alpha subunit

Interleukin 12 receptor

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