A mega-analysis of genome-wide association studies for major depressive disorder

Ripke, Stephan; R. Wray, Naomi; M. Lewis, Cathryn; P. Hamilton, Steven; M. Weissman, Myrna; Breen, Gerome; M. Byrne, Enda; Blackwood, Douglas; I. Boomsma, Dorret; Cichon, Sven; C. Heath, Andrew; Holsboer, Florian; Lucae, Susanne; A. F. Madden, Pamela; G. Martin, Nicholas; McGuffin, Peter; Muglia, Pierandrea; M. Nöethen, Markus; P Penninx, Brenda; L. Pergadia, Michele; B. Potash, James; Rietschel, Marcella; Y. Lin, D.; Müller‐Myhsok, Bertram; Shi, Jianxin; Steinberg, Stacy; J. Grabe, Hans; Lichtenstein, Paul; K. E. Magnusson, Patrik; H. Perlis, Roy; Preisig, Martin; W. Smoller, Jordan; Stefánsson, Kāri; Uher, Rudolf; Kutalik, Zoltán; E. Tansey, Katherine; Teumer, Alexander; Viktorin, Alexander; R. Barnes, Michael; Bettecken, Thomas; B. Binder, Elisabeth; Breuer, René; M. Castro, Víctor; Churchill, Susanne; Coryell, William; Craddock, Nick; Craig, Ian; Czamara, Darina; J. C. de Geus, Eco; Degenhardt, Franziska; Farmer, Anne; Fava, Maurizio; Frank, Josef; S. Gainer, Vivian; Gallagher, Patience; D. Gordon, Scott; Goryachev, Sergey; Groß, Magdalena; Guipponi, Michel; K. Henders, Anjali; Herms, Stefan; B. Hickie, Ian; Hoefels, Susanne; J.G. Hoogendijk, Witte; Hottenga, Jouke‐Jan; V. Iosifescu, Dan; Ising, Marcus; D. Jones, Ian; Jones, Lisa; Jung-Ying, Tzeng; A. Knowles, James; S. Kohane, Isaac; Kohli, Martin; Korszun, Ania; Landén, Mikael; Lawson, William; Lewis, Glyn; J. MacIntyre, Donald; Maier, Wolfgang; Mattheisen, Manuel; J. McGrath, Patrick; M. McIntosh, Andrew; McLean, Alan; M. Middeldorp, Christel; Middleton, Lefkos; M Montgomery, Grant; N. Murphy, Shawn; Nauck, Matthias; A. Nolen, Willem; R. Nyholt, Dale; O‘Donovan, Michael; Óskarsson, Högni; L. Pedersen, Nancy; A. Scheftner, William; Schulz, Andrea; G. Schulze, Thomas; I. Shyn, Stanley; Sigurðsson, Engilbert; L. Slager, Susan; H. Smit, Johannes; Stefánsson, Hreinn; Steffens, Michael; E. Thorgeirsson, Thorgeir; Tozzi, Federica; Treutlein, Jens; Uhr, Manfred; J.C.G. van den Oord, Edwin; van Grootheest, Gerard; Völzke, Henry; B. Weilburg, Jeffrey; Willemsen, Gonneke; G. Zitman, Frans; M. Neale, Benjamin; J. Daly, Mark; F. Levinson, Douglas; F. Sullivan, Patrick

doi:10.1038/mp.2012.21

Public

A mega-analysis of genome-wide association studies for major depressive disorder

Published in Molecular Psychiatry • Apr 3, 2012

Authors:

Stephan Ripke

Naomi R. Wray

Cathryn M. Lewis

Abstract

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chro...

Subject

Major depressive disorder

Genome-wide association study

Single-nucleotide polymorphism

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