The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

Arico, Sébastien; Petiot, Anne; Bauvy, Chantal; F. Dubbelhuis, Peter; J. Meijer, Alfred; Codogno, Patrice; Ogier‐Denis, Éric

doi:10.1074/jbc.c100319200

Public

The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

Published in Journal of Biological Chemistry • Sep 1, 2001

Authors:

Sébastien Arico

Anne Petiot

Chantal Bauvy

Abstract

The tumor suppressor PTEN is a dual protein and phosphoinositide phosphatase that negatively controls the phosphatidylinositol (PI) 3-kinase/protein kinase B (Akt/PKB) signaling pathway. Interleukin-13 via the activation of the class I PI 3-kinase has been shown to inhibit the macroautophagic pathwa...

Subject

PTEN

Phosphatidylinositol

Suppressor

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