AMPK Activation Stimulates Myofibrillar Protein Degradation and Expression of Atrophy-Related Ubiquitin Ligases by Increasing FOXO Transcription Factors in C2C12 Myotubes

Nakashima, Kazuki; Yakabe, Yoko

doi:10.1271/bbb.70057

Public

AMPK Activation Stimulates Myofibrillar Protein Degradation and Expression of Atrophy-Related Ubiquitin Ligases by Increasing FOXO Transcription Factors in C2C12 Myotubes

Published in Bioscience Biotechnology and Biochemistry • Jul 23, 2007

Authors:

Kazuki Nakashima

Yoko Yakabe

Abstract

In skeletal muscle, AMP-activated protein kinase (AMPK) is a metabolic master switch regulating glucose and lipid metabolism. Recently, AMPK has been implicated in the control of protein synthesis in skeletal muscle, but the effect of AMPK activation on myofibrillar protein degradation has yet to be...

Subject

Myogenesis

AMPK

Protein degradation

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