NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

Wick, Wolfgang; Hartmann, Christian; Engel, Corinna; Stoffels, Mandy; Felsberg, Jörg; Stockhammer, Florian; Sabel, Michael; Koeppen, Susanne; Ketter, Ralf; Meyermann, Richard; Rapp, Marion; Meisner, C; D. Kortmann, Rolf; Pietsch, Torsten; D. Wiestler, Otmar; Ernemann, Ulrike; Bamberg, Michael; Reifenberger, Guido; von Deimling, Andreas; Weller, Michael

doi:10.1200/jco.2009.23.6497

Public

NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

Published in Journal of Clinical Oncology • Nov 9, 2009

Authors:

Wolfgang Wick

Christian Hartmann

Corinna Engel

Abstract

PURPOSE: The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared efficacy and safety of radiotherapy followed by chemotherapy at progression with the reverse sequence in patients with newly diagnosed anaplastic gliomas. PATIENTS AND METHOD...

Subject

Lomustine

Procarbazine

Temozolomide

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