Lineage Tracing Reveals Lgr5
                    <sup>+</sup>
                    Stem Cell Activity in Mouse Intestinal Adenomas

G. Schepers, Arnout; J. Snippert, Hugo; E. Stange, Daniel; van den Born, Maaike; H. van Es, Johan; van de Wetering, Marc; Clevers, Hans

doi:10.1126/science.1224676

Public

Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas

Published in Science • Aug 10, 2012

NobleIDark:/48914/w1/20260526/8FEC9B12Record on NobleID

Authors:

Arnout G. Schepers

,

Hugo J. Snippert

,

Daniel E. Stange

Abstract

Cancer Stem Cells in Color One of the liveliest debates in contemporary cancer research centers on whether cancer stem cells (CSCs) exist and, if so, how these cells are defined phenotypically. CSCs are hypothesized to be a small population of cells within a tumor that are endowed with the unique ca...

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