IL-17 produced by neutrophils regulates IFN-γ–mediated neutrophil migration in mouse kidney ischemia-reperfusion injury

L, Li; Huang, Liping; L. Vergis, Amy; Ye, Hong; Bajwa, Amandeep; Narayan, Vivek; M. Strieter, Robert; L. Rosin, Diane; D. Okusa, Mark

doi:10.1172/jci38702

Public

IL-17 produced by neutrophils regulates IFN-γ–mediated neutrophil migration in mouse kidney ischemia-reperfusion injury

Published in Journal of Clinical Investigation • Dec 28, 2009

Authors:

Li L

Liping Huang

Amy L. Vergis

Abstract

The IL-23/IL-17 and IL-12/IFN-gamma cytokine pathways have a role in chronic autoimmunity, which is considered mainly a dysfunction of adaptive immunity. The extent to which they contribute to innate immunity is, however, unknown. We used a mouse model of acute kidney ischemia-reperfusion injury (IR...

Subject

Immunology

Kidney

Interleukin 17

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