IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.

L, Li; L, Huang; AL, Vergis; H, Ye; A, Bajwa; V, Narayan; RM, Strieter; DL, Rosin; MD, Okusa

doi:10.1172/jci38702

Public

IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.

Shared by NobleBlocks on Dec 14, 2009 • 12:00 AM UTC

Authors:

Li L

Huang L

Vergis AL

Abstract

The IL-23/IL-17 and IL-12/IFN-gamma cytokine pathways have a role in chronic autoimmunity, which is considered mainly a dysfunction of adaptive immunity. The extent to which they contribute to innate immunity is, however, unknown. We used a mouse model of acute kidney ischemia-reperfusion injury (IR...

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