Therapeutic effects of hypertonic saline on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats*

Shih, Chih‐Chin; Chen, Shiu‐Jen; Chen, Ann; Wu, Jeng‐Yuan; Liaw, Wen‐Jinn; Wu, Chin‐Chen

doi:10.1097/ccm.0b013e318173f982

Public

Therapeutic effects of hypertonic saline on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats*

Published in Critical Care Medicine • May 29, 2008

Authors:

Chih‐Chin Shih

Shiu‐Jen Chen

Ann Chen

Abstract

OBJECTIVE: Significant mortality in patients with sepsis results from the development of multiple organ dysfunction syndrome. Small-volume resuscitation with 7.5% NaCl hypertonic saline has been proposed to restore physiologic hemodynamics in hemorrhagic shock. Therefore, we hypothesized that hypert...

Subject

Medicine

Hypertonic saline

Septic shock

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