Impact of Transmission Intensity and Age on Plasmodium falciparum Density and Associated Fever: Implications for Malaria Vaccine Trial Design

Beadle, Christine; D. McElroy, Peter; N. Oster, Charles; C. Beier, John; J Oloo, A; K. Onyango, Fred; K. Chumo, David; D Bales, J; A Sherwood, J; L. Hoffman, Stephen

doi:10.1093/infdis/172.4.1047

Public

Impact of Transmission Intensity and Age on Plasmodium falciparum Density and Associated Fever: Implications for Malaria Vaccine Trial Design

Published in The Journal of Infectious Diseases • Oct 1, 1995

Authors:

Christine Beadle

Peter D. McElroy

Charles N. Oster

Abstract

To facilitate design of vaccine trials, malaria was studied in 6-month- to 6-year-old Kenyans during high (HI) and low intensity transmission seasons. During 84 days after cure, exposure to infected mosquitoes was 9-fold greater in the HI group, yet incidence of P. falciparum infection was increased...

Subject

Parasitemia

Malaria

Malaria vaccine

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