Mutation of <i>FOXL2</i> in Granulosa-Cell Tumors of the Ovary

P. Shah, Sohrab; Köbel, Martin; Senz, Janine; D. Morin, Ryan; Clarke, Blaise; C. Wiegand, Kimberly; Leung, Gillian; Zayed, Abdalnasser; Mehl, Erika; E. Kalloger, Steve; Sun, Mark; Giuliany, Ryan; Yorida, Erika; J.M. Jones, Steven; Varhol, Richard; D. Swenerton, Kenneth; Miller, Dianne; B. Clement, Philip; Crane, Colleen; Madore, Jason; Provencher, Diane; C. K. Leung, Peter; DeFazio, Anna; Khattra, Jaswinder; Turashvili, Gulisa; Zhao, Yongjun; Zeng, Thomas; N. Mark Glover, J.; C. Vanderhyden, Barbara; Zhao, Chengquan; Parkinson, Christine; Jimenez‐Liñan, Mercedes; D.L. Bowtell, David; Mes‐Masson, Anne‐Marie; D. Brenton, James; Aparício, Samuel; Boyd, Niki; Hirst, Martin; Blake Gilks, C.; A. Marra, Marco; G. Huntsman, David

doi:10.1056/nejmoa0902542

Public

Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary

Published in New England Journal of Medicine • Jun 10, 2009

Authors:

Sohrab P. Shah

Martin Köbel

Janine Senz

Abstract

BACKGROUND: Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, their histopathological diagnosis can be challenging, and there is no curative treatment beyond surgery. METHODS: We analyzed f...

Subject

Biology

Missense mutation

Transcriptome

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