BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites

Ray, Reena; Gao, Chen; Vande Velde, Christine; Cizeau, Jeannick; Hoon Park, Jae; C. Reed, John; Daniel Gietz, R.; H. Greenberg, Arnold

doi:10.1074/jbc.275.2.1439

Public

BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites

Published in Journal of Biological Chemistry • Jan 1, 2000

Authors:

Reena Ray

Chen Gao

Christine Vande Velde

Abstract

BNIP3 (formerly NIP3) is a pro-apoptotic, mitochondrial protein classified in the Bcl-2 family based on limited sequence homology to the Bcl-2 homology 3 (BH3) domain and COOH-terminal transmembrane (TM) domain. BNIP3 expressed in yeast and mammalian cells interacts with survival promoting proteins ...

Subject

Bcl-xL

Mitochondrion

Programmed cell death

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