Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.

Suthanthiran, Manikkam; E. Anderson, Mary; K. Sharma, Vijay; Meister, A

doi:10.1073/pnas.87.9.3343

Public

Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.

Published in Proceedings of the National Academy of Sciences • May 1, 1990

Authors:

Manikkam Suthanthiran

Mary E. Anderson

Vijay K. Sharma

Abstract

Regulation of proliferation of normal human T lymphocytes (T cells) by glutathione (GSH) was explored with T-cell activation models that do not require accessory cell signals. L-Buthionine-(S,R)-sulfoximine (BSO), which inactivates gamma-glutamylcysteine synthetase and therefore inhibits GSH synthes...

Subject

Glutathione

Buthionine sulfoximine

Molecular biology

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