mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Cheng, Shih-Chin; Quintin, Jessica; A. Cramer, Robert; M. Shepardson, Kelly; Saeed, Sadia; Kumar, Vinod; J. Giamarellos-Bourboulis, Evangelos; H. A. Martens, Joost; Appukudige Rao, Nagesha; Aghajanirefah, Ali; R. Manjeri, Ganesh; Li, Yang; C. Ifrim, Daniela; J. W. Arts, Rob; M. J. W. van der Veer, Brian; M. T. Deen, Peter; Logie, Colin; A. O’Neill, Luke; Willems, Peter; L. van de Veerdonk, Frank; W. M. van der Meer, Jos; Ng, Aylwin; A. B. Joosten, Leo; Wijmenga, Cisca; G. Stunnenberg, Hendrik; J. Xavier, Ramnik; G. Netea, Mihai

doi:10.1126/science.1250684

Public

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Shared by NobleBlocks on Sep 26, 2014 • 12:00 AM UTC

Authors:

Shih-Chin Cheng

Jessica Quintin

Robert A. Cramer

Abstract

A BLUEPRINT of immune cell development To determine the epigenetic mechanisms that direct blood cells to develop into the many components of our immune system, the BLUEPRINT consortium examined the regulation of DNA and RNA transcription to dissect the molecular traits that govern blood cell differe...

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