Therapeutic Angiogenesis With Intramuscular NV1FGF Improves Amputation-free Survival in Patients With Critical Limb Ischemia

Nikol, Sigrid; Baumgärtner, Iris; Van Belle, Éric; Diehm, Curt; Visonà, Adriana; C. Capogrossi, Maurizio; Ferreira-Maldent, Nicole; Gallino, Augusto; G. Wyatt, Michael; Wijesinghe, L.D.; Fusari, Melissa; Stéphan, Dominique; Emmerich, Joseph; Pompilio, Giulio; Vermassen, Frank; Pham, Emmanuel; Grek, Vincent; Coleman, Michael; Meyer, François

doi:10.1038/mt.2008.33

Public

Therapeutic Angiogenesis With Intramuscular NV1FGF Improves Amputation-free Survival in Patients With Critical Limb Ischemia

Published in Molecular Therapy • Apr 3, 2008

Authors:

Sigrid Nikol

Iris Baumgärtner

Éric Van Belle

Abstract

This study evaluated the efficacy and safety of intramuscular administration of NV1FGF, a plasmid-based angiogenic gene delivery system for local expression of fibroblast growth factor 1 (FGF-1), versus placebo, in patients with critical limb ischemia (CLI). In a double-blind, randomized, placebo-co...

Subject

Medicine

Critical limb ischemia

Placebo

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