Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

Messager, Sophie; E. Chatzidaki, Emmanouella; Ma, Dan; G. Hendrick, Alan; Zahn, Dirk; B. Dixon, John; R. Thresher, Rosemary; Malinge, Isabelle; Lomet, Didier; Carlton, Mark; H Colledge, William; Caraty, Alain; Aparício, Samuel

doi:10.1073/pnas.0409330102

Public

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

Published in Proceedings of the National Academy of Sciences • Jan 21, 2005

Authors:

Sophie Messager

Emmanouella E. Chatzidaki

Dan Ma

Abstract

We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice and men for the pubertal onset of pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to oc...

Subject

Kisspeptin

Internal medicine

Endocrinology

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