Defective macrophage function in aquaporin-3 deficiency.

N, Zhu; X, Feng; C, He; H, Gao; L, Yang; Q, Ma; L, Guo; Y, Qiao; H, Yang; T, Ma

doi:10.1096/fj.11-182808

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Defective macrophage function in aquaporin-3 deficiency.

Shared by NobleBlocks on Aug 24, 2011 • 12:00 AM UTC

Authors:

Zhu N

Feng X

He C

Abstract

Macrophages play an essential role in innate immunity. We found that mouse resident peritoneal macrophages (mRPMs) express the aquaglyceroporin aquaporin-3 (AQP3) in a plasma membrane pattern. AQP3-deficient (AQP3(-/-)) mice showed significantly greater mortality than wild-type (AQP3(+/+)) mice in a...

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