Mesenchymal stem cells regulate epithelial–mesenchymal transition and tumor progression of pancreatic cancer cells

Kabashima‐Niibe, Ayano; Higuchi, Hajime; Takaishi, Hiromasa; Masugi, Yohei; Matsuzaki, Yumi; Mabuchi, Yo; Funakoshi, Shinsuke; Adachi, Masayuki; Hamamoto, Yasuo; Kawachi, Shigeyuki; Aiura, Koichi; Kitagawa, Yuko; Sakamoto, Michiie; Hibi∥, Toshifumi

doi:10.1111/cas.12059

Public

Mesenchymal stem cells regulate epithelial–mesenchymal transition and tumor progression of pancreatic cancer cells

Published in Cancer Science • Nov 2, 2012

Authors:

Ayano Kabashima‐Niibe

Hajime Higuchi

Hiromasa Takaishi

Abstract

Cancer-associated fibroblasts contribute to cancer progression that is caused by epithelial-mesenchymal transition (EMT). Recently, mesenchymal stem cells (MSCs) were found to be the major candidate involved in the development of tumor-promoting cancer stroma. Here we report that α-smooth muscle act...

Subject

Mesenchymal stem cell

Pancreatic cancer

Epithelial–mesenchymal transition

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