Frameshift peptide-derived T-cell epitopes: A source of novel tumor-specific antigens

Linnebacher, Michael; Gebert, Johannes; Rudy, W.; M. Woerner, Stefan; P. Yuan, Yan; Bork, Peer; von Knebel Doeberitz, Magnus

doi:10.1002/ijc.1298

Public

Frameshift peptide-derived T-cell epitopes: A source of novel tumor-specific antigens

Published in International Journal of Cancer • Jan 1, 2001

Authors:

Michael Linnebacher

Johannes Gebert

W. Rudy

Abstract

Microsatellite instability (MSI) caused by defective DNA mismatch repair (MMR) is a hallmark of hereditary nonpolyposis colorectal cancers (HNPCC) but also occurs in about 15% of sporadic tumors. If instability affects microsatellites in coding regions, translational frameshifts lead to truncated pr...

Subject

Frameshift mutation

Biology

Microsatellite instability

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