Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease

C. Cohen, Jonathan; Boerwinkle, Eric; H. Mosley, Thomas; H. Hobbs, Helen

doi:10.1056/nejmoa054013

Public

Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease

Published in New England Journal of Medicine • Mar 22, 2006

Authors:

Jonathan C. Cohen

Eric Boerwinkle

Thomas H. Mosley

Abstract

BACKGROUND: A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in plasma LDL cholesterol is not known. We examined the effect of DNA-sequence variations that reduce plasma levels of LD...

Subject

PCSK9

Medicine

Internal medicine

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