Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease

Garcia, Pierre; Youssef, Ihsen; Kristian Utvik, Jo; Florent‐Béchard, Sabrina; Barthélémy, Vanassa; Malaplate‐Armand, Catherine; Kriem, Badreddine; Stenger, Christophe; Koziel, Violette; Olivier, Jean‐Luc; Escanyé, Marie‐Christine; Hanse, Marine; Allouche, Ahmad; Desbène, Cédric; T. Yen, Frances; Bjerkvig, Rolf; Oster, Thierry; P. Niclou, Simone; Pillot, Thierry

doi:10.1523/jneurosci.4182-09.2010

Public

Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease

Published in Journal of Neuroscience • Jun 2, 2010

Authors:

Pierre Garcia

Ihsen Youssef

Jo Kristian Utvik

Abstract

The development of novel therapeutic strategies for Alzheimer's disease (AD) represents one of the biggest unmet medical needs today. Application of neurotrophic factors able to modulate neuronal survival and synaptic connectivity is a promising therapeutic approach for AD. We aimed to determine whe...

Subject

Ciliary neurotrophic factor

Neuroscience

Neurotrophic factors

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