Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

K. Witkiewicz, Agnieszka; A. McMillan, Elizabeth; Balaji, Uthra; Baek, GuemHee; Lin, Wan-Chi; C. Mansour, John; Mollaee, Mehri; Wagner, Kay‐Uwe; Koduru, Prasad; C. Yopp, Adam; A. Choti, Michael; J. Yeo, Charles; A. McCue, Peter; A. White, Michael; S. Knudsen, Erik

doi:10.1038/ncomms7744

Public

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Published in Nature Communications • Apr 9, 2015

Authors:

Agnieszka K. Witkiewicz

Elizabeth A. McMillan

Uthra Balaji

Abstract

Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109 micro-dissected PDA cases were subjected to whole-exome sequencing. Microdissection enriches tumour cellularity and enhances mutation calling. He...

Subject

Biology

KRAS

Exome sequencing

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!