Inhibition of TMEM16A Expression Suppresses Growth and Invasion in Human Colorectal Cancer Cells

Sui, Yujie; Sun, Meiyan; Wu, Fei; Yang, Longfei; Di, Weihua; Zhang, Guizhen; Zhong, Lili; Ma, Zhiming; Zheng, Jinhao; Fang, Xuedong; Ma, Tonghui

doi:10.1371/journal.pone.0115443

Public

Inhibition of TMEM16A Expression Suppresses Growth and Invasion in Human Colorectal Cancer Cells

Published in PLoS ONE • Dec 26, 2014

Authors:

Yujie Sui

Meiyan Sun

Fei Wu

Abstract

Metastasis leads to poor prognosis in colorectal cancer patients, and there is a growing need for new therapeutic targets. TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as a calcium-activated chloride channel (CaCC) and is reported to be overexpressed in several malignancies; however, i...

Subject

Small hairpin RNA

Cancer research

Flow cytometry

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