The <i>C9orf72</i> GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

Mori, Kohji; Weng, Shih‐Ming; Arzberger, Thomas; May, Stephanie; Rentzsch, Kristin; Kremmer, Elisabeth; Schmid, Bettina; A. Kretzschmar, Hans; Cruts, Marc; Van Broeckhoven, Christine; Haass, Christian; Edbauer, Dieter

doi:10.1126/science.1232927

Public

The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

Published in Science • Feb 8, 2013

Authors:

Kohji Mori

Shih‐Ming Weng

Thomas Arzberger

Abstract

Unusual Aggregates Several recent papers have revealed the unexpected genetic and pathological overlap between frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The most common genetic cause is the GGGGCC hexanucleotide repeat expansion upstream of the C9orf72 coding ...

Subject

C9orf72

Frontotemporal lobar degeneration

Frontotemporal dementia

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