BAFF selectively enhances the survival of plasmablasts generated from human memory B cells

T. Avery, Danielle; L. Kalled, Susan; I. Ellyard, Julia; Ambrose, Christine; A. Bixler, Sarah; Thien, Marilyn; Brink, Robert; Mackay, Fabienne; D. Hodgkin, Philip; G. Tangye, Stuart

doi:10.1172/jci18025

Public

BAFF selectively enhances the survival of plasmablasts generated from human memory B cells

Published in Journal of Clinical Investigation • Jul 15, 2003

Authors:

Danielle T. Avery

Susan L. Kalled

Julia I. Ellyard

Abstract

The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells. This process must be strictly regulated to ensure sufficient humoral immunity while avoiding production of pathogenic autoantibodies. BA...

Subject

B-cell activating factor

CD40

Biology

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