A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies

Chapman, Kathryn; Sewell, Fiona; Allais, Linda; Delongeas, Jean‐Luc; Donald, Elizabeth; Festag, Matthias; Kervyn, Sophie; Ockert, Deborah; Nogués, Vicente; Palmer, Helen; Popović, Marija; Roosen, Wendy; Schoenmakers, Ankie; Somers, Kevin; Stark, Claudia; Stei, Peter; Robinson, Sally

doi:10.1016/j.yrtph.2013.04.003

Public

A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies

Published in Regulatory Toxicology and Pharmacology • Apr 19, 2013

Authors:

Kathryn Chapman

Fiona Sewell

Linda Allais

Abstract

Short term toxicity studies are conducted in animals to provide information on major adverse effects typically at the maximum tolerated dose (MTD). Such studies are important from a scientific and ethical perspective as they are used to make decisions on progression of potential candidate drugs, and...

Subject

Toxicity

Dosing

Weight loss

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!