A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

Parkinson Study Group QE3 Investigators, The; Flint Beal, M.; Oakes, David; Shoulson, Ira; Henchcliffe, Claire; R. Galpern, Wendy; Haas, Richard; L. Juncos, Jorge; G. Nutt, John; Voss, Tiffini; Ravina, Bernard; M. Shults, Clifford; Helles, Karen; Snively, Victoria; Lew, Mark; Griebner, Brian; Watts, Arthur; Gao, Shan; Pourcher, Emmanuelle; Bond, Louisette; Kompoliti, Katie; Agarwal, Pinky; Sia, Cherissa; Jog, Mandar; Cole, Linda; Sultana, Munira; Kurlan, Roger; Hegeman Richard, Irene; Deeley, Cheryl; Waters, Cheryl; Figueroa, Angel; Arkun, Ani; Brodsky, Matthew; G. Ondo, William; Hunter, Christine; Jimenez‐Shahed, Joohi; Palao, Alicia; M. Miyasaki, Janis; So, Julie; W. Tetrud, James; Reys, Liza; Smith, Katharine; Singer, Carlos; Blenke, Anita; Russell, David; Cotto, Candace; H. Friedman, Joseph; C. Lannon, Margaret; Zhang, Lin; Drasby, Edward; Kumar, Rajeev; Subramanian, Thyagarajan; Stuppy Ford, Donna; A. Grimes, David; Côté, Diane; Conway, Jennifer; Siderowf, Andrew; L. Evatt, Marian; Sommerfeld, Barbara; Lieberman, Abraham; S. Okun, Michael; L. Rodriguez, Ramon; Merritt, Stacy; Swartz, Camille; R. Wayne Martin, W.; King, Pamela; Stover, Natividad; Guthrie, Stephanie; L. Watts, Ray; Ahmed, Anwar; H. Fernandez, Hubert; Winters, Adrienna; Mari, Zoltán; M. Dawson, Ted; Dunlop, Becky; Feigin, Andrew; Shannon, Barbara; J. Nirenberg, Melissa; Ogg, Mattson; A. Ellias, Samuel; Thomas, Cathi-Ann; Frei, Karen; Bódis-Wollner, Iván; Glazman, Sofya; A. Mayer, Thomas; A. Hauser, Robert; Pahwa, Rajesh; Langhammer, April; Ranawaya, Ranjit; Derwent, Lorelei; D. Sethi, Kapil; Farrow, Buff; Prakash, Rajan; Litvan, Irene; Robinson, Annette; Sahay, Alok; Gartner, Maureen; K. Hinson, Vanessa; Markind, Samuel; Pelikan, Melisa; S. Perlmutter, Joel; M Hartlein, Johanna; Molho, Eric; Evans, Sharon; H. Adler, Charles; Duffy, Amy; Lind, Marlene; Elmer, Lawrence; Davis, Kathy; Spears, Julia; Wilson, Stephanie; A. Leehey, Maureen; Hermanowicz, Neal; Niswonger, Shari; A. Shill, Holly; Obradov, Sanja; Rajput, Alex; Cowper, Marilyn; Lessig, Stephanie; Song, David; Fontaine, Deborah; Zadikoff, Cindy; Williams, Karen; Blindauer, Karen; Bergholte, Jo; Schindler Propsom, Clara; Stacy, Mark; Field, Joanne; Mihaila, Dragos; Chilton, Mark; Y. Uc, Ergun; Sieren, Jeri; K. Simon, David; Kraics, Lauren; Silver, Althea; T. Boyd, James; W. Hamill, Robert; T. Ingvoldstad, Christopher; Young, Jennifer; Thomas, Karen; K. Kostyk, Sandra; Wojcieszek, Joanne; F. Pfeiffer, Ronald; Panisset, Michel; Beland, Monica; G. Reich, Stephen; Cines, Michelle; Zappala, Nancy; Rivest, J.; M. Zweig, Richard; Pepper Lumina, L.; Lynn Hilliard, Colette; Grill, Stephen; Kellermann, Marye; Tuite, Paul; Rolandelli, Susan; Jung Kang, Un; Young, Joan; Rao, Jayaraman; Cook, Maureen; Severt, Lawrence; Boyar, Karyn

doi:10.1001/jamaneurol.2014.131

Public

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

Published in JAMA Neurology • Mar 25, 2014

Authors:

The Parkinson Study Group QE3 Investigators

M. Flint Beal

David Oakes

Abstract

IMPORTANCE: Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A previous phase II study suggested possible clinic...

Subject

Parkinsonism

Coenzyme Q10

Parkinson's disease

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