Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.

Nagele, Peter; Duma, Andreas; Kopec, Michael; Anne Gebara, Marie; Parsoei, Alireza; Walker, Marie; Janski, Alvin; N Panagopoulos, Vassilis; Cristancho, Pilar; Philip Miller, J; F Zorumski, Charles; R Conway, Charles

doi:10.1016/j.biopsych.2014.11.016

Public

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.

Shared by NobleBlocks on Jul 1, 2015 • 12:00 AM UTC

Authors:

Peter Nagele

Andreas Duma

Michael Kopec

Abstract

BACKGROUND: N-methyl-D-aspartate receptor antagonists, such as ketamine, have rapid antidepressant effects in patients with treatment-resistant depression (TRD). We hypothesized that nitrous oxide, an inhalational general anesthetic and N-methyl-D-aspartate receptor antagonist, may also be a rapidly...

Subject

Major depression

Nitrous oxide

Treatment-resistant depression

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