Ca2+‐dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β‐treated astrocytes and in a model of A lzheimer's disease

Alberdi, Elena; Wyssenbach, Ane; Alberdi, María; Victoria Sánchez‐Gómez, María; Cavaliere, Fabio; J. Rodrı́guez, José; Verkhratsky, Alexei; Matute, Carlos

doi:10.1111/acel.12054

Public

Ca2+‐dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β‐treated astrocytes and in a model of A lzheimer's disease

Published in Aging Cell • Feb 15, 2013

Authors:

Elena Alberdi

Ane Wyssenbach

María Alberdi

Abstract

Neurotoxic effects of amyloid β peptides are mediated through deregulation of intracellular Ca(2+) homeostasis and signaling, but relatively little is known about amyloid β modulation of Ca(2+) homeostasis and its pathological influence on glia. Here, we found that amyloid β oligomers caused a cytop...

Subject

Astrogliosis

Biology

Astrocyte

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