The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Kirisako, Takayoshi; Ichimura, Yoshinobu; Okada, Hisashi; Kabeya, Yukiko; Mizushima, Noboru; Yoshimori, Tamotsu; Ohsumi, Mariko; Takao, Toshifumi; Noda, Takeshi; Ohsumi, Yoshinori

doi:10.1083/jcb.151.2.263

Public

The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Published in The Journal of Cell Biology • Oct 16, 2000

Authors:

Takayoshi Kirisako

Yoshinobu Ichimura

Hisashi Okada

Abstract

Autophagy and the Cvt pathway are examples of nonclassical vesicular transport from the cytoplasm to the vacuole via double-membrane vesicles. Apg8/Aut7, which plays an important role in the formation of such vesicles, tends to bind to membranes in spite of its hydrophilic nature. We show here that ...

Subject

Vacuole

Cytoplasm

Deubiquitinating enzyme

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