The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Kirisako, Takayoshi; Ichimura, Yoshinobu; Okada, Hisashi; Kabeya, Yukiko; Mizushima, Noboru; Yoshimori, Tamotsu; Ohsumi, Mariko; Takao, Toshifumi; Noda, Takeshi; Ohsumi, Yoshinori

doi:10.1083/jcb.151.2.263

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The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Shared by NobleBlocks on Oct 16, 2000 • 12:00 AM UTC

Authors:

Takayoshi Kirisako

Yoshinobu Ichimura

Hisashi Okada

Abstract

Autophagy and the Cvt pathway are examples of nonclassical vesicular transport from the cytoplasm to the vacuole via double-membrane vesicles. Apg8/Aut7, which plays an important role in the formation of such vesicles, tends to bind to membranes in spite of its hydrophilic nature. We show here that ...

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