Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

Bauer, Stefan; J. Kirschning, Carsten; Häcker, Hans; Redecke, Vanessa; Hausmann, Susanne; Akira, Shizuo; Wagner, Hermann; B. Lipford, Grayson

doi:10.1073/pnas.161293498

Public

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

Published in Proceedings of the National Academy of Sciences • Jul 24, 2001

Authors:

Stefan Bauer

Carsten J. Kirschning

Hans Häcker

Abstract

The Toll-like receptor (TLR) family consists of phylogenetically conserved transmembrane proteins, which function as mediators of innate immunity for recognition of pathogen-derived ligands and subsequent cell activation via the Toll/IL-1R signal pathway. Here, we show that human TLR9 (hTLR9) expres...

Subject

TLR9

Toll-Like Receptor 9

CpG site

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