Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N -acetyltransferase-2, and xanthine oxidase with the ″Cooperstown cocktail”

S. Streetman, Daniel

doi:10.1067/mcp.2000.109519

Public

Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N -acetyltransferase-2, and xanthine oxidase with the ″Cooperstown cocktail”

Published in Clinical Pharmacology & Therapeutics • Oct 1, 2000

Authors:

Daniel S. Streetman

Abstract

BACKGROUND: Simultaneous administration of several probes enhances the utility of phenotyping, but poor specificity, side effects, and use of drugs not approved by the Food and Drug Administration limit the usefulness of prior phenotyping cocktails. OBJECTIVES: To evaluate potential drug-drug intera...

Subject

Dextromethorphan

Omeprazole

Pharmacology

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