Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

Agathangelidis, Andreas; Darzentas, Nikos; Hadzidimitriou, Anastasia; Brochet, Xavier; Murray, Fiona; Yan, Xiao‐Jie; Davis, Zadie; J. van Gastel-Mol, Ellen; Tresoldi, Cristina; C. Chu, Charles; Cahill, Nicola; Giudicelli, Véronique; Tichý, Boris; Bredo Pedersen, Lone; Foroni, Letizia; Bonello, Lisa; Januś, Agnieszka; E. Smedby, Karin; Anagnostopoulos, Αchilles; Merle‐Béral, Hélène; Laoutaris, Nikolaos; Juliusson, Gunnar; Francia di Celle, Paola; Pospı́šilová, Šárka; Jurlander, Jesper; H. Geisler, Christian; Tsaftaris, Athanasios; Lefranc, Marie‐Paule; W. Langerak, Anton; Oscier, David; Chiorazzi, Nicholas; Belessi, Chrysoula; Davi, Frédéric; Rosenquist, Richard; Ghia, Paolo; Σταματόπουλος, Κώστας

doi:10.1182/blood-2011-11-393694

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Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

Published in Blood • Mar 14, 2012

Authors:

Andreas Agathangelidis

Nikos Darzentas

Anastasia Hadzidimitriou

Abstract

Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However, several issues need revisiting, including the criteria for identification of BCR stereotypy and its actual frequency as we...

Subject

breakpoint cluster region

Chronic lymphocytic leukemia

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