Nramp
 2
 is mutated in the anemic Belgrade (
 b
 ) rat: Evidence of a role for Nramp2 in endosomal iron transport

D. Fleming, Mark; A. Romano, Michelle; A. Su, Maureen; M. Garrick, Laura; D. Garrick, Michael; C. Andrews, Nancy

doi:10.1073/pnas.95.3.1148

Public

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

Shared by NobleBlocks on Feb 3, 1998 • 12:00 AM UTC

Authors:

Mark D. Fleming

Michelle A. Romano

Maureen A. Su

Abstract

The Belgrade ( b ) rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal reticulocyte iron uptake and gastrointestinal iron absorption. The b reticulocyte defect appears to be failure of iron transport out of endosomes within the transferrin cycle. Aspec...

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