Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

Fujita, Naoya; Sato, Saori; Tsuruo, Takashi

doi:10.1074/jbc.m306614200

Public

Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

Published in Journal of Biological Chemistry • Nov 26, 2003

Authors:

Naoya Fujita

Saori Sato

Takashi Tsuruo

Abstract

The cyclin-dependent kinase inhibitor p27Kip1 plays an important role in cell cycle regulation. The cyclin-dependent kinase-inhibitory activity of p27Kip1 is regulated by changes in its concentration and its subcellular localization. Several reports suggest that phosphorylation of p27Kip1 at serine ...

Subject

Phosphorylation

Kinase

Threonine

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