Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5

Liu, Li; Cao, Yichen; Chen, Charles; Zhang, Xiaomei; McNabola, Angela; Wilkie, Dean; M. Wilhelm, Scott; Lynch, Mark; Carter, Christopher

doi:10.1158/0008-5472.can-06-1377

Public

Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5

Published in Cancer Research • Dec 15, 2006

Authors:

Li Liu

Yichen Cao

Charles Chen

Abstract

Angiogenesis and signaling through the RAF/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK cascade have been reported to play important roles in the development of hepatocellular carcinomas (HCC). Sorafenib (BAY 43-9006, Nexavar) is a multikinase inhibitor with...

Subject

Sorafenib

MAPK/ERK pathway

Cancer research

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