Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors

K. Mellinghoff, Ingo; Y. Wang, Maria; Vivanco, Igor; A. Haas‐Kogan, Daphne; Zhu, Shaojun; Q. Dia, Ederlyn; Lu, Kan; Yoshimoto, Koji; H. Huang, Julie; J. Chute, Dennis; L. Riggs, Bridget; Horvath, Steve; M. Liau, Linda; K. Cavenee, Webster; Nagesh Rao, P.; Beroukhim, Rameen; C. Peck, Timothy; C. Lee, Jeffrey; R. Sellers, William; Stokoe, David; D. Prados, Michael; F. Cloughesy, Timothy; L. Sawyers, Charles; S. Mischel, Paul

doi:10.1056/nejmoa051918

Public

Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors

Published in New England Journal of Medicine • Nov 9, 2005

Authors:

Ingo K. Mellinghoff

Maria Y. Wang

Igor Vivanco

Abstract

BACKGROUND: The epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed, or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to EGFR kinase inhibitors. The mechanism of responsiveness of glioblastomas to these inhibitors is unknown. METHODS: We s...

Subject

PTEN

Epidermal growth factor receptor

Medicine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!