Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARγ expression and activating Wnt signaling pathway

Jiang, Yini; Zhang, Yanqiong; Zhang, Haojun; Zhu, Bin; Li, Ping; Lu, Chao; Xu, Ying; Chen, Weiheng; Lin, Na

doi:10.1177/1535370213519215

Public

Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARγ expression and activating Wnt signaling pathway

Published in Experimental Biology and Medicine • Feb 7, 2014

Authors:

Yini Jiang

Yanqiong Zhang

Haojun Zhang

Abstract

Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fi...

Subject

Pravastatin

Endocrinology

Internal medicine

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