Efficacy and safety of once-weekly bortezomib in multiple myeloma patients

Bringhen, Sara; Larocca, Alessandra; Rossi, Davide; Cavalli, Maide; Genuardi, Mariella; Ria, Roberto; Gentili, Silvia; Patriarca, Francesca; Nozzoli, Chiara; Levi, Anna; Guglielmelli, Tommasina; Benevolo, Giulia; Callea, Vincenzo; Rizzo, Vincenzo; Cangialosi, Clotilde; Musto, Pellegrino; De Rosa, Luca; Marina Liberati, Anna; Grasso, Mariella; Falcone, Antonietta; Evangelista, Andrea; Cavo, Michèle; Gaïdano, Gianluca; Boccadoro, Mario; Palumbo, Antonio

doi:10.1182/blood-2010-07-294983

Public

Efficacy and safety of once-weekly bortezomib in multiple myeloma patients

Published in Blood • Aug 31, 2010

Authors:

Sara Bringhen

Alessandra Larocca

Davide Rossi

Abstract

In a recent phase 3 trial, bortezomib-melphalan-prednisone-thalidomide followed by maintenance treatment with bortezomib-thalidomide demonstrated superior efficacy compared with bortezomib-melphalan-prednisone. To decrease neurologic toxicities, the protocol was amended and patients in both arms rec...

Subject

Bortezomib

Multiple myeloma

Lenalidomide

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