Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.

Millet, L.; Vidal, Hubert; Andréelli, Fabrizio; Larrouy, Dominique; P. Riou, J.; Ricquier, Daniel; Laville, Martine; Langin, Dominique

doi:10.1172/jci119811

Public

Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.

Published in Journal of Clinical Investigation • Dec 1, 1997

Authors:

L. Millet

Hubert Vidal

Fabrizio Andréelli

Abstract

Uncoupling protein-2 and -3 (UCP2 and UCP3) are mitochondrial proteins that show high sequence homology with the brown adipocyte-specific UCP1. UCP1 induces heat production by uncoupling respiration from ATP synthesis. UCP2 is widely expressed in human tissues, whereas UCP3 expression seems restrict...

Subject

UCP3

Uncoupling protein

Endocrinology

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