In Vivo Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy Reveals Increased Pyruvate Carboxylase Flux in an Insulin-Resistant Mouse Model

Lee, Philip; Leong, Waifook; Tan, Trish; Lim, Miangkee; Han, Weiping; K. Radda, George

doi:10.1002/hep.26028

Public

In Vivo Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy Reveals Increased Pyruvate Carboxylase Flux in an Insulin-Resistant Mouse Model

Published in Hepatology • Aug 22, 2012

Authors:

Philip Lee

Waifook Leong

Trish Tan

Abstract

UNLABELLED: The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP). Despite the importance of hepatic metabolic aberrations in diabetes development, there is currently no molecular probe that allows measurement of hepatic glucon...

Subject

In vivo

Carbon flux

Flux (metallurgy)

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