A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia

Li, Mei; Sun, Meiling; Cao, Lijuan; Gu, Jin‐Hua; Ge, Jianbin; Chen, Jieyu; Han, Rong; Qin, Yuanyuan; Zhou, Zhipeng; Ding, Yu‐Qiang; Qin, Zheng‐Hong

doi:10.1523/jneurosci.4655-13.2014

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A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia

Published in Journal of Neuroscience • May 28, 2014

Authors:

Mei Li

Meiling Sun

Lijuan Cao

Abstract

TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose. We hypothesized that TIGAR plays a neuroprotective role in brain ischemia as neurons do not rely on glycolysis but are vulnerable ...

Subject

Pentose phosphate pathway

Neuroprotection

Downregulation and upregulation

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