A Human Interleukin-12/23 Monoclonal Antibody for the Treatment of Psoriasis

G. Krueger, Gerald; G. Langley, Richard; L. Leonardi, Craig; Yeilding, Newman; Guzzo, Cynthia; Wang, Yuhua; T. Dooley, Lisa; Lebwohl, Mark

doi:10.1056/nejmoa062382

Public

A Human Interleukin-12/23 Monoclonal Antibody for the Treatment of Psoriasis

Published in New England Journal of Medicine • Feb 7, 2007

Authors:

Gerald G. Krueger

Richard G. Langley

Craig L. Leonardi

Abstract

BACKGROUND: Skin-infiltrating lymphocytes expressing type 1 cytokines have been linked to the pathophysiology of psoriasis. We evaluated the safety and efficacy of a human interleukin-12/23 monoclonal antibody in treating psoriasis. METHODS: In this double-blind, placebo-controlled trial, 320 patien...

Subject

Medicine

Psoriasis

Monoclonal antibody

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