Phase II Study of Paclitaxel Plus the Protein Kinase C Inhibitor Bryostatin-1 in Advanced Pancreatic Carcinoma

Lam, Anthony; A. Sparano, Joseph; Vinciguerra, Vincent; J. Ocean, Allyson; J. Christos, Paul; S. Höchster, Howard; Camacho, Fernando; Goel, Sanjay; Mani, Sridhar; Kaubisch, Andreas

doi:10.1097/coc.0b013e3181a31920

Public

Phase II Study of Paclitaxel Plus the Protein Kinase C Inhibitor Bryostatin-1 in Advanced Pancreatic Carcinoma

Published in American Journal of Clinical Oncology • Mar 26, 2010

Authors:

Anthony Lam

Joseph A. Sparano

Vincent Vinciguerra

Abstract

PURPOSE: To determine the efficacy and toxicity of the protein kinase C inhibitor bryostatin-1 plus paclitaxel in patients with advanced pancreatic carcinoma. METHODS: Each treatment cycle consisted of paclitaxel 90 mg/m by intravenous infusion over 1 hour on days 1, 8, and 16, plus bryostatin 25 mc...

Subject

Medicine

Cancer research

Pancreatic carcinoma

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