Functional Roles of Src and Fgr in Ovarian Carcinoma

Kim, Hye‐Sun; Dong Han, Hee; N. Armaiz-Peña, Guillermo; L. Stone, Rebecca; Ji Nam, Eun; Lee, Jeong‐Won; M.K. Shahzad, Mian; M. Nick, Alpa; Joo Lee, Sun; Roh, Ju‐Won; Nishimura, Masato; S. Mangala, Lingegowda; Bottsford-Miller, Justin; E. Gallick, Gary; Lopez‐Berestein, Gabriel; K. Sood, Anil

doi:10.1158/1078-0432.ccr-10-2081

Public

Functional Roles of Src and Fgr in Ovarian Carcinoma

Published in Clinical Cancer Research • Feb 8, 2011

Authors:

Hye‐Sun Kim

Hee Dong Han

Guillermo N. Armaiz-Peña

Abstract

PURPOSE: Src is an attractive target because it is overexpressed in a number of malignancies, including ovarian cancer. However, the effect of Src silencing on other Src family kinases (SFKs) is not known. We hypothesized that other SFK members could compensate for the lack of Src activity. EXPERIME...

Subject

Gene silencing

Proto-oncogene tyrosine-protein kinase Src

Cancer research

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