Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

Yoshida, Minoru; Seiki, Motoharu; Yamaguchi, Kazunari; Takatsuki, Kiyoshi

doi:10.1073/pnas.81.8.2534

Public

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

Published in Proceedings of the National Academy of Sciences • Apr 1, 1984

Authors:

Minoru Yoshida

Motoharu Seiki

Kazunari Yamaguchi

Abstract

The genome of human T-cell leukemia virus (HTLV) was surveyed in fresh tumor cells of 163 patients with lymphoma and leukemia from the southwest part of Japan where adult T-cell leukemia (ATL) is endemic. Leukemic cells of all 88 cases of ATL tested so far were found to contain the provirus genome a...

Subject

Provirus

Leukemia

Virology

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