Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.

SS, Sisodia; EH, Koo; K, Beyreuther; A, Unterbeck; DL, Price

doi:10.1126/science.1691865

Public

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.

Shared by NobleBlocks on Apr 1, 1990 • 12:00 AM UTC

Authors:

Sisodia SS

Koo EH

Beyreuther K

Abstract

The beta-amyloid protein (beta/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. APP is an integral membrane glycoprotein and is secreted as a carboxyl-terminal truncated molecule. APP cleavage, which is a membrane-associ...

Discussions