Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes

A. Nauck, Michael; Frid, Anders; Hermansen, Kjeld; S. Shah, Nalini; Tankova, Tsvetalina; Mitha, Ismail; Zdravković, Milan; Düring, Maria; R. Matthews, David; the LEAD-2 Study Group, for

doi:10.2337/dc08-1355

Public

Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes

Published in Diabetes Care • Oct 17, 2008

Authors:

Michael A. Nauck

Anders Frid

Kjeld Hermansen

Abstract

OBJECTIVE: The efficacy and safety of adding liraglutide (a glucagon-like peptide-1 receptor agonist) to metformin were compared with addition of placebo or glimepiride to metformin in subjects previously treated with oral antidiabetes (OAD) therapy. RESEARCH DESIGN AND METHODS: In this 26-week, dou...

Subject

Liraglutide

Glimepiride

Medicine

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