The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome

Friščić, Tomislav; Childs, S.L.; A. A. Rizvi, Syed; Jones, William

doi:10.1039/b815174a

Public

The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome

Published in CrystEngComm • Dec 19, 2008

Authors:

Tomislav Friščić

S.L. Childs

Syed A. A. Rizvi

Abstract

Mechanochemical liquid-assisted grinding (LAG) and sonochemical (SonicSlurry) techniques have been compared as methods to construct four model pharmaceutical cocrystals involving theophylline and caffeine as pharmaceutical ingredients and L-malic or L-tartaric acid as pharmaceutical cocrystal former...

Subject

Cocrystal

Solubility

Chemistry

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