Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

Barnden, Megan; Allison, Jan; R. Heath, William; Carbone, Federico

doi:10.1046/j.1440-1711.1998.00709.x

Public

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

Published in Immunology and Cell Biology • Feb 1, 1998

Authors:

Megan Barnden

Jan Allison

William R. Heath

Abstract

We describe the generation of ovalbumin (OVA)-specific, MHC class II-restricted alpha beta T cell receptor (TCR) transgenic mice. Initial attempts at generating these transgenic mice utilized heterologous regulatory elements to drive the expression of cDNA genes encoding the separate alpha- and beta...

Subject

T-cell receptor

Transgene

Heterologous

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