Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

J Barnden, Megan; Allison, Jan; R Heath, William; R Carbone, Francis

doi:10.1046/j.1440-1711.1998.00709.x

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Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

Shared by NobleBlocks on Feb 1, 1998 • 12:00 AM UTC

Authors:

Megan J Barnden

Jan Allison

William R Heath

Abstract

We describe the generation of ovalbumin (OVA)‐specific, MHC class II‐restricted αβ T cell receptor (TCR) transgenic mice. Initial attempts at generating these transgenic mice utilized heterologous regulatory elements to drive the expression of cDNA genes encoding the separate α‐ and β‐chains of the ...

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