Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy

Sen, Dwaipayan; Balakrishnan, Balaji; Gabriel, Nishanth; Agrawal, Prachi; Roshini, Vaani; Samuel, Rekha; Srivastava, Alok; R. Jayandharan, Giridhara

doi:10.1038/srep01832

Public

Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy

Published in Scientific Reports • May 13, 2013

Authors:

Dwaipayan Sen

Balaji Balakrishnan

Nishanth Gabriel

Abstract

Despite significant advancements with recombinant AAV2 or AAV8 vectors for liver directed gene therapy in humans, it is well-recognized that host and vector-related immune challenges need to be overcome for long-term gene transfer. To overcome these limitations, alternate AAV serotypes (1-10) are be...

Subject

Genetic enhancement

Adeno-associated virus

Serotype

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